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Mechanism review Wan and colleagues (2023, Journal of Translational Medicine ) and Kong and colleagues (2023, Diabetes & Metabolism Journal ) reviewed AMPK activation, mitochondria-to-nucleus signaling, and the link between MOTS-c and aging-related metabolic disease

These characteristics allowed the field to conduct replicable and robust experiments, such as generating SC-islets from patients with T1D and subjecting them to environmental stressors (219, 220)

Multiple studies have investigated berberine's effect on GLP-1 secretion

As research continues to evolve, therapies targeting multiple metabolic pathways may continue shaping the future of metabolic health and long-term weight management